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Ocular involvement in Castleman's disease. Response to radiotherapy
1Department of Surgery, University of Massachusetts Medical School, Worcester.
Ophthalmology
|November 1, 1989
Summary
Castleman disease can affect the eyes, causing vision loss and retinal detachment. Radiotherapy successfully treated ocular manifestations, restoring good vision without evidence of lymphoma.
Area of Science:
- Ophthalmology
- Oncology
- Hematology
Background:
- Castleman disease is a rare lymphoproliferative disorder.
- Ocular involvement in Castleman disease is uncommon but can be severe.
Observation:
- A young man with Castleman disease presented with decreased vision, chromatopsia, and left exophthalmos.
- Ocular findings included optic disc and choroidal infiltration, retinal elevation, and depigmented RPE/choroidal areas.
- A significant retinal detachment developed in the left eye.
Findings:
- The patient's retinal detachment responded well to radiotherapy.
- Vision recovered significantly following treatment.
- Subtle leptomeningeal involvement resolved spontaneously during observation.
Implications:
- This case highlights the importance of considering Castleman disease in the differential diagnosis of unexplained ocular inflammation and vision loss.
- Radiotherapy can be an effective treatment for ocular manifestations of Castleman disease.
- Early recognition and management of ocular involvement may prevent permanent vision impairment.