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Centrifugation

Centrifugation

Centrifugation is a separation technique based on differences in density or size. It is commonly used to separate solids from aqueous interferents. During centrifugation, the sample is placed in centrifugation tubes and spun at high angular velocity, which allows centrifugal force to act differentially on the different densities or masses of the components. After spinning, the supernatant liquid is decanted. Depending on the specific application, either the pellet or the supernatant is retained...

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Related Experiment Video

Updated: Apr 7, 2026

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Published on: April 16, 2016

Detection methods for centrifugal microfluidic platforms.

Robert Burger¹, Letizia Amato¹, Anja Boisen¹

¹Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

Biosensors & Bioelectronics

|July 14, 2015

Summary

This summary is machine-generated.

Centrifugal microfluidics enables affordable, portable biosensing. This review covers essential biosensors and detection methods, including optical, mechanical, and electrical principles for lab-on-a-disc systems.

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Last Updated: Apr 7, 2026

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Fluorescence detection methods for microfluidic droplet platforms

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Area of Science:

Microfluidics
Biosensing
Analytical Chemistry

Background:

Centrifugal microfluidics offers potential for affordable, user-friendly, and portable biosensing.
Automated and integrated complex assay protocols are achievable using lab-on-a-disc systems.
Fluidic unit operations like mixing, metering, routing, and separation are established.

Purpose of the Study:

To review biosensors and readout methods for centrifugal microfluidics.
To highlight the importance of detection strategies for integrated systems.
To cover various detection principles applicable to this platform.

Main Methods:

Literature review focused on centrifugal microfluidics.
Analysis of different biosensor types and their integration.
Categorization of detection principles: optical, mechanical, and electrical.

Main Results:

A variety of fluidic unit operations are available for centrifugal microfluidic systems.
Detection strategies are critical for the functionality of integrated lab-on-a-disc devices.
Optical, mechanical, and electrical detection methods are applicable.

Conclusions:

Centrifugal microfluidics is a promising field for advanced biosensing.
The choice of detection method significantly impacts the performance of centrifugal microfluidic systems.
Further development in biosensor and readout integration is key for realizing the full potential.