Using the M-CHAT-R/F to Identify Developmental Concerns in a High-Risk 18-Month-Old Sibling Sample

Area of Science:

• Developmental Pediatrics
• Autism Spectrum Disorder Research
• Early Childhood Development

Background:

• Infant siblings of children with autism spectrum disorder (ASD) have a high recurrence risk.
• Early identification of ASD markers is crucial in this high-risk population.
• The M-CHAT-R/F is validated for low-risk children but its utility in high-risk infants is less studied.

Purpose of the Study:

• To evaluate the effectiveness of the M-CHAT-R/F in identifying developmental concerns in high-risk infant siblings.
• To assess the M-CHAT-R/F's performance in a very young, high-risk population.

Main Methods:

• Screened 74 infant siblings using the M-CHAT-R/F at 18 months of age.
• Assessed diagnostic outcomes between 18 and 43 months.
• Included as part of a larger population-based study.

Main Results:

• The M-CHAT-R/F demonstrated the highest positive predictive value for identifying any developmental concern, including ASD and language delay.
• 33% of siblings who underwent follow-up evaluations received ASD diagnoses.
• An additional 22% of siblings exhibited other developmental concerns.

Conclusions:

• Failing the M-CHAT-R/F at 18 months is a significant predictor of future developmental differences or delays.
• Close developmental monitoring is essential for high-risk infant siblings.
• The M-CHAT-R/F is a valuable tool for early screening in this population.