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Updated: Apr 7, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
Published on: April 3, 2015
Epithelia migration: a spatiotemporal interplay between contraction and adhesion
Boris Rubinstein1, Inês Mendes Pinto2
1a Stowers Institute for Medical Research ; Kansas City , KS USA.
Abstract:
Epithelial tissues represent 60% of the cells that form the human body and where more than 90% of all cancers derived. Epithelia transformation and migration involve altered cell contractile mechanics powered by an actomyosin-based cytoskeleton and influenced by cell-cell and cell-extracellular matrix interactions. A balance between contractile and adhesive forces regulates a large number of cellular and tissue properties crucial for epithelia migration and tumorigenesis. In this review, the forces driving normal epithelia transformation into highly motile and invasive cells and tissues will be discussed.
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