Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

6.1K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smoking-Associated DNA Methylation and Offspring Caries Experience: Findings from the GUSTO Study.

Journal of dental research·2025
Same author

Robot-Assisted Reduction of the Ankle Joint via Multi-Body 3D-2D Image Registration.

IEEE transactions on medical robotics and bionics·2025
Same author

Multi-Body 3D-2D Registration for Robot-Assisted Joint Reduction: Preclinical Evaluation in the Ankle Syndesmosis.

Proceedings of SPIE--the International Society for Optical Engineering·2023
Same author

Publisher Correction: Brain charts for the human lifespan.

Nature·2022
Same author

Brain charts for the human lifespan.

Nature·2022
Same author

Malnutrition in early life and its neurodevelopmental and cognitive consequences: a scoping review.

Nutrition research reviews·2021

Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.9K

Ethnic differences in insulin sensitivity and beta-cell function among Asian men.

V M H Tan1, Y S Lee2, K Venkataraman3

  • 11] Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore [2] Department of Paediatric, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Nutrition & Diabetes
|July 21, 2015
PubMed
Summary

Lean Asian Indians are less insulin sensitive than Chinese and Malays, with lower beta-cell function. Chinese individuals exhibit the highest insulin sensitivity, while Malays show higher glucose excursions post-meal. These ethnic differences suggest varied pathways to type 2 diabetes.

More Related Videos

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
10:28

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

12.7K
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

3.7K

Related Experiment Videos

Last Updated: Apr 6, 2026

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.9K
Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
10:28

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

12.7K
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

3.7K

Area of Science:

  • Metabolic Health
  • Endocrinology
  • Human Physiology

Background:

  • Lean Asian Indians exhibit lower insulin sensitivity compared to Chinese and Malays.
  • Pancreatic beta-cell function differences across these ethnic groups remain understudied.

Purpose of the Study:

  • To investigate pancreatic beta-cell function in relation to insulin sensitivity.
  • To compare these metabolic parameters among Chinese, Malay, and Asian Indian men in Singapore.

Main Methods:

  • Sub-group analysis of 59 lean, normoglycemic adult males (Chinese, Malay, Asian Indian).
  • Insulin sensitivity assessed via homeostatic model assessment-insulin resistance, euglycemic-hyperinsulinemic clamp (ISI-clamp), and Matsuda insulin sensitivity index (ISI-Mat).
  • Beta-cell function evaluated using homeostatic model assessment-beta-cell function, insulinogenic index, and insulin secretion index.

Main Results:

  • Asian Indians had higher body fat and waist circumference despite similar BMI.
  • Chinese were most insulin sensitive; Asian Indians were least insulin sensitive.
  • Malays showed higher postprandial glucose excursion but similar insulin response to other groups.

Conclusions:

  • Significant ethnic variations exist in insulin sensitivity among lean Asians.
  • Asian Indians are least insulin sensitive, while Chinese are most sensitive.
  • Malays exhibit impaired beta-cell response relative to glucose excursion, suggesting distinct type 2 diabetes mellitus pathways.