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Updated: Apr 6, 2026
A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
Published on: January 20, 2023
Effect of Antioxidant Echinochrome A on Bleomycin-Induced Pulmonary Fibrosis
O A Lebed'ko1, B Ya Ryzhavskii, O V Demidova
1Khabarovsk Division of the Far-Eastern Scientific Center for Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Science - Research Institute of Maternal and Child Welfare, Khabarovsk, Russia, leoaf@mail.ru.
Abstract:
We studied the protective effect of antioxidant echinochrome A on bleomycin-induced pulmonary fibrosis in rats at the early stages of postnatal ontogeny. Administration of echinochrome A was shown to reduce the severity of bleomycin-induced oxidative stress in the lungs, prevented the development of hypertrophy of interalveolar connective tissue and peribronchial lymphoid infiltration, and normalized the ratio of volume densities of interalveolar septa and alveolar lumen.
