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lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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Related Experiment Video

Updated: Apr 6, 2026

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Widespread noncoding circular RNAs in plants.

Chu-Yu Ye¹, Li Chen², Chen Liu¹

¹Institute of Crop Sciences, Zhejiang University, Hangzhou, 310058, China.

The New Phytologist

|July 25, 2015

Summary

This summary is machine-generated.

Circular RNAs (circRNAs) are widespread in plants like rice and Arabidopsis. These noncoding molecules show conserved features and diverse expression, suggesting a critical regulatory role in plant biology.

Keywords:

Arabidopsis thaliana Oryza sativa back splicing circular RNA (circRNA)exonic circRNA noncoding RNA

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Identification of Circular RNAs using RNA Sequencing

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Published on: November 14, 2019

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Published on: July 28, 2017

Area of Science:

Plant molecular biology
Genomics
Noncoding RNA research

Background:

Noncoding circular RNAs (circRNAs) are known regulatory molecules in animals.
Plant circRNAs have been largely understudied.
Understanding plant circRNAs is crucial for deciphering novel regulatory mechanisms.

Purpose of the Study:

To perform genome-wide identification and characterization of circRNAs in plants (Oryza sativa and Arabidopsis thaliana).
To compare features of plant circRNAs with those of animal circRNAs.
To investigate the expression patterns and potential functions of plant circRNAs.

Main Methods:

Genome-wide identification of circRNAs using public RNA-Seq data from Oryza sativa and Arabidopsis thaliana.
Bioinformatic analysis of circRNA features, including flanking introns and sequence characteristics.
Experimental validation of identified rice exonic circRNAs.
Analysis of circRNA expression patterns under different conditions (e.g., phosphate starvation).
Comparison of expression profiles between circRNAs and their parent genes.

Main Results:

Identification of 12,037 circRNAs in Oryza sativa and 6,012 in Arabidopsis thaliana.
Experimental validation confirmed 56% of sampled rice exonic circRNAs.
Conservation of parent genes for over 700 exonic circRNAs between rice and Arabidopsis.
Plant circRNAs exhibit distinct features, including longer flanking introns with fewer repetitive elements compared to animal circRNAs.
Diverse expression patterns observed, with 27 rice circRNAs differentially expressed under phosphate conditions.
A positive correlation found between the expression of some circRNAs and their parent genes.

Conclusions:

Circular RNAs are widespread and conserved regulatory molecules in plants.
Plant and animal circRNAs share some features but also possess distinct characteristics.
Plant circRNAs, particularly those involved in stress responses like phosphate starvation, represent a critical class of noncoding regulators.