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Updated: Apr 6, 2026

Germ Cell Transplantation and Testis Tissue Xenografting in Mice
Published on: February 6, 2012
Late Relapse of Testicular Germ Cell Tumors
Matthew J O'Shaughnessy1, Darren R Feldman2, Brett S Carver1
1Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 353 East 68th Street, New York, NY 10065, USA.
Abstract:
Germ cell tumors of the testis have an overall survival rate greater than 90% as a result of a successful multidisciplinary approach to management. Late relapse affects a subset of patients however, and tends to be chemorefractory and the overall prognosis is poor. Surgery is the mainstay in management of late relapse but salvage chemotherapy can be successful. In this review, the clinical presentation and detection of late relapse, clinical outcomes, and predictors of survival in late relapse and the importance of a multidisciplinary treatment approach for successful management of late relapse are discussed.
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