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Randomised Comparative Study on Propofol and Diazepam as a Sedating Agent in Day Care Surgery
Amit S Nirwan1, Neha Jain2, Micheal Pragasm2
1Department of Oral and Maxillofacial Surgery, College of Dental Science and Hospital, Rau, Indore, India.
Journal of Maxillofacial and Oral Surgery
|July 31, 2015
Summary
Propofol is a superior intravenous sedative compared to Diazepam for oral surgery. It offers faster action, better amnesia, and quicker recovery, improving patient compliance and enabling earlier discharge.
Area of Science:
- Anesthesiology and Pharmacology
- Oral and Maxillofacial Surgery
Background:
- Sedation is crucial for managing apprehensive patients during outpatient oral surgery.
- Intravenous sedatives like Diazepam and Propofol are commonly used.
- A qualitative comparison is needed to determine the optimal agent for specific procedures.
Purpose of the Study:
- To qualitatively compare the efficacy of Diazepam and Propofol for intravenous sedation.
- To evaluate their usefulness in apprehensive and uncooperative patients undergoing day care oral surgical procedures.
Main Methods:
- A comparative study involving 20 adult patients, with 10 receiving Propofol and 10 receiving Diazepam.
- Evaluation parameters included onset of action, recovery time, anterograde amnesia, patient cooperation, surgeon's convenience, and side effects.
Main Results:
- Propofol demonstrated a superior sedative profile compared to Diazepam.
- Key advantages of Propofol included rapid and predictable onset, profound amnesia, and faster recovery.
- These benefits facilitated earlier patient discharge and enhanced patient compliance.
Conclusions:
- Propofol is identified as an ideal sedative agent for day care oral surgical procedures.
- Its pharmacokinetic and clinical profile offers significant advantages over Diazepam in this setting.
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