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Updated: Apr 6, 2026
Author Spotlight: Development and Evaluation of a Standardized Rat Model for Calvarial Suture-Bony Composite Defects
Published on: May 10, 2024
Evaluation of Crystallized Biosilicate in the Reconstruction of Calvarial Defects
Marcelo Rodrigues Azenha1, Suzie Aparecida de Lacerda2, Heloísa Fonseca Marão3
1Dentistry School of Ribeirão Preto, Stomatology Department, Universidade de São Paulo (USP), Avenida do café s/n, Bairro Monte Alegre, Ribeirão Preto, Brazil ; Dentistry School of Araçatuba, Universidade Estadual Paulista (UNESP), São Paulo, Brazil.
Introduction:
The objective of this study was to assess the bone repair process of crystallized Biosilicate in surgically created defects on rats' calvaria. This biomaterial was recently developed for odontological use.
Materials And Methods:
We used fifteen rats (rattus norvegicus albinus, Wistar), and two 5 mm surgical defects were performed on each of them; the defects were made with trephine drill on the calvarium region prior to the biomaterial placement. Groups were divided as follows: Group 1-defect filled with clot; Group 2-defect filled with crystallized Biosilicate. After 7, 14 and 28 days the animals were killed, the parts were retrieved and slides were prepared for histological studies.
Results:
Bone formation was satisfactory in all groups, with direct contact between biomaterial surface and bone and absence of infection signs. The 28 days periods showed better results, and statistically significant difference between Clot Group (90.2 %) and Biosilicate (58 %; p = 0.002) was seen, regarding presence of bone tissue on the surgical defects.
Conclusion:
Our study revealed that defects filled with clot present better results on bone formation compared to crystallized Biosilicate, which is considered a biocompatible material with favorable osteoconductive properties.
