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Evaluation of medication adherence in Lebanese hypertensive patients
Mohammad Yassine1, Amal Al-Hajje1, Sanaa Awada1
1Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Clinical Pharmacy Department, Doctoral School of Sciences & Technology, Lebanese University, Beirut, Lebanon.
Insights
Medication adherence in Lebanese hypertensive patients is crucial for cardiovascular health. Over half of patients showed high adherence, but factors like forgetfulness and complex regimens negatively impact blood pressure control.
Area of Science:
- Cardiology
- Pharmacology
- Public Health
Background:
- Hypertension management is critical for cardiovascular disease outcomes.
- Poor medication adherence leads to adverse health events and increased healthcare costs.
- Understanding adherence factors in specific populations is essential for targeted interventions.
Purpose of the Study:
- To evaluate antihypertensive medication adherence in Lebanese patients.
- To determine the proportion of adherent patients using a validated scale.
- To identify predictors of medication adherence in this population.
Main Methods:
- A cross-sectional study involving 210 hypertensive outpatients in Beirut.
- Utilized the 8-item Modified Morisky Medication Adherence Scale (MMMAS) for assessment.
- Employed bivariate and logistic regression analyses to identify adherence predictors.
Main Results:
- 50.5% of patients exhibited high medication adherence.
- Controlled blood pressure and combination drug use predicted high adherence.
- Forgetfulness, complex regimens, and side effects were linked to low adherence.
- Calcium channel blockers were associated with increased adherence.
Conclusions:
- Multidisciplinary interventions and healthcare provider education are needed to improve adherence.
- Addressing specific barriers like forgetfulness and regimen complexity is vital.
- Targeted strategies can enhance medication adherence and cardiovascular health outcomes.
Abstract:
Controlling hypertension is essential in cardiovascular diseases. Poor medication adherence is associated with poor disease outcomes, waste of healthcare resources, and contributes to reduced blood pressure control. This study evaluates treatment adherence to antihypertensive therapy in Lebanese hypertensive patients by estimating the proportion of adherent hypertensive patients using a validated tool and investigates what factors predict this behavior. A questionnaire-based cross-sectional study was conducted on a random sample of 210 hypertensive outpatients selected from clinics located in tertiary-care hospitals and from private cardiology clinics located in Beirut. Adherence level was measured using a validated 8-item Modified Morisky Medication Adherence Scale (MMMAS). Among 210 patients, 50.5% showed high adherence, 27.1% medium adherence, and 22.4% low adherence to medication. Mean MMMAS score was 6.59±2.0. In bivariate analyses, having controlled blood pressure (p=0.003) and taking a combination drug (p=0.023) were predictors of high adherence. Forgetfulness (p<0.01), complicated drug regimen (p=0.001), and side effects (p=0.006) were predictors of low adherence after multiple liner regression. Logistic regression results showed that calcium channel blockers (p=0.030) were associated with increased adherence levels. In conclusion, developing multidisciplinary intervention programs to address the factors identified, in addition to educational strategies targeting healthcare providers, are necessary to enhance patient adherence.
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