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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Related Experiment Video

Updated: Apr 6, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
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[Autoimmune enteropathy].

Urpo Kinnunen, Katri Vuopala, Katri Kaukinen

    Duodecim; Laaketieteellinen Aikakauskirja
    |August 5, 2015
    PubMed
    Summary

    Autoimmune enteropathy (AIE) is an infant condition causing severe diarrhea and malabsorption due to immune damage to the small intestine. Treatment with immunosuppressants shows variable success, with prognosis linked to intestinal damage and other symptoms.

    Area of Science:

    • Gastroenterology
    • Immunology
    • Pediatrics

    Context:

    • Autoimmune enteropathy (AIE) is a rare condition primarily affecting infants.
    • Characterized by chronic diarrhea, malabsorption, and immune-mediated intestinal damage.
    • Often presents with unresponsiveness to dietary modifications.

    Purpose:

    • To define the key features, diagnostic markers, and clinical course of autoimmune enteropathy.
    • To review the current understanding of AIE pathophysiology and treatment outcomes.

    Summary:

    • AIE involves immune system attacking the small intestine, leading to significant malabsorption and diarrhea.
    • Histological findings include lymphocyte deposits in the mucosa.
    • Antibodies against enterocytes or goblet cells are frequently observed in patients.

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  • Immunosuppressive therapy is the mainstay of treatment, with variable efficacy.

    • Impact:

    • Highlights the autoimmune basis of AIE, differentiating it from other enteropathies.
    • Emphasizes the importance of early diagnosis and appropriate management for better patient outcomes.
    • Provides a foundation for future research into targeted therapies for AIE.