Deep Mutational Scanning: Library Construction, Functional Selection, and High-Throughput Sequencing

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Lea M Starita1, Stanley Fields2

  • 1Department of Genome Sciences, University of Washington, Seattle, Washington 98195;

Cold Spring Harbor Protocols
|August 5, 2015
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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.