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Immunohistochemistry 2015: Protein correlates of molecular alterations and predictive testing

Jason L Hornick1

  • 1Department of Pathology Brigham and Women׳s Hospital Harvard Medical School Boston, MA.

Seminars in Diagnostic Pathology
|August 8, 2015
PubMed
Abstract

No abstract available in PubMed .

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Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
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