Nanomedical strategies for targeting skin microbiomes

Area of Science:

• Dermatology
• Nanotechnology
• Pharmacology

Background:

• Nanoparticles serve as effective drug delivery systems for skin infections, offering advantages over conventional methods.
• These benefits include enhanced solubility, stability, permeability, bioavailability, and targeted delivery with fewer side effects.
• The use of nanoparticles for treating skin microbiome-related diseases is a growing area of research.

Purpose of the Study:

• To review recent advancements in nanomedical strategies for drug delivery in treating skin infections.
• To systematically describe various nanocarriers and their physicochemical properties for antimicrobial therapy.
• To highlight nanoparticle applications in treating appendageal bacteria (e.g., acne), non-appendageal bacteria, and fungi.

Main Methods:

• Literature review of nanomedical strategies for drug delivery in skin infections.
• Systematic description of nanocarrier types: liposomes, microemulsions, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and polymeric nanoparticles.
• Analysis of physicochemical properties and antibacterial activity of nanoparticles.

Main Results:

• Various nanocarriers demonstrate significant potential for antimicrobial therapy against skin pathogens.
• Nanoparticles show promise in treating appendageal bacterial infections, such as acne.
• The review details the structures, properties, and efficacy of different nanocarrier systems.

Conclusions:

• Nanoparticles represent a promising frontier in treating bacterial and fungal skin infections due to their superior drug delivery capabilities.
• Further research is needed to overcome current obstacles and fully realize the potential of nanocarriers in infection management.
• Nanomedical approaches offer targeted and effective solutions for various skin microbiome-related diseases.