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Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Loose Connective Tissue01:26

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Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
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Fibrous Proteins00:55

Fibrous Proteins

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Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
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Connective Tissue Fibers and Ground Substance01:17

Connective Tissue Fibers and Ground Substance

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One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...
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Related Experiment Video

Updated: Apr 5, 2026

Murine Dermal Fibroblast Isolation by FACS
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Fibroblastic connective tissue nevus.

Moises J Velez1, Steven D Billings2, Joshua A Weaver1

  • 1Department of Pathology, Summa Akron City Hospital, Akron, OH, USA.

Journal of Cutaneous Pathology
|August 14, 2015
PubMed
Summary
This summary is machine-generated.

Fibroblastic connective tissue nevus (FCTN) is a benign skin lesion. This study details three FCTN cases, highlighting their features and overlap with dermatomyofibroma.

Keywords:
dermatomyofibromaelectron microscopyfibroblastfibroblastic connective tissue nevusmyofibroblast

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Area of Science:

  • Dermatopathology
  • Cutaneous Neoplasms
  • Soft Tissue Tumors

Background:

  • Fibroblastic connective tissue nevus (FCTN) is a recently identified benign mesenchymal lesion of the skin.
  • FCTN expands the classification of connective tissue nevi.
  • Understanding FCTN is crucial for accurate dermatologic diagnosis.

Observation:

  • Three cases of FCTN in young women (ages 10-32) are presented.
  • Lesions appeared as nodules or plaques on the neck, flank, and thigh.
  • Histopathology revealed spindle cell proliferation with entrapped adnexal structures.

Findings:

  • Spindle cells exhibited fibroblastic features.
  • Immunohistochemistry showed CD34 positivity in two cases; one case was negative for CD34, SMA, desmin, and S100.
  • Electron microscopy confirmed fibroblastic differentiation in two cases, a novel finding for FCTN.

Implications:

  • FCTN shares clinical and morphologic similarities with dermatomyofibroma.
  • Accurate diagnosis of FCTN requires careful clinicopathologic correlation.
  • Further research is needed to fully delineate FCTN and its relationship to other fibroblastic lesions.