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Updated: Apr 5, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Application of 3D NMR for Structure Determination of Peptide Natural Products
Fan Zhang1, Navid Adnani1, Emmanuel Vazquez-Rivera2
1Pharmaceutical Sciences Division, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Abstract:
Despite the advances in NMR, structure determination is often slow and constitutes a bottleneck in natural products discovery. Removal of this bottleneck would greatly improve the throughput for antibiotic discovery as well as other therapeutic areas. Overall, faster structure methods for structure determination will serve the natural products community in a broad manner. This report describes the first application of 3D NMR for elucidation of two microbially produced peptide natural products with novel structures. The methods are cost-effective and greatly improve the confidence in a proposed structure.
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