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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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[Cryoglobulinemic vasculitis with renal involvement: A historic aspect of the problem]

N B Gordovskaya1, L V Kozlovskaya2, S Yu Milovanova3

  • 1Department of Nephrology and Hemodialysis, Faculty for Postgraduate Professional Training of Physicians, I.M. Sechenov First Moscow Medical University, Ministry of Health of Russia, Moscow, Russia.

Terapevticheskii Arkhiv
|August 19, 2015
PubMed

Insights

This study details the progression of cryoglobulinemia, from its essential form to hepatitis C virus-associated cryoglobulinemic vasculitis. It highlights advancements in understanding causes, diagnosis, kidney damage, and treatment for HCV-related vasculitis with kidney issues.

Area of Science:

  • Nephrology
  • Hepatology
  • Rheumatology

Context:

  • Cryoglobulinemia is a condition involving abnormal proteins in the blood.
  • Hepatitis C virus (HCV) infection is a significant cause of cryoglobulinemic vasculitis.
  • Renal involvement is a serious complication of this condition.

Purpose:

  • To outline the diagnostic and therapeutic journey of cryoglobulinemia.
  • To illustrate the evolution of managing HCV-related cryoglobulinemic vasculitis with renal disease.
  • To present updated approaches based on clinical case studies over several decades.

Summary:

  • The paper reviews the study of cryoglobulinemia, focusing on its progression to HCV-associated cryoglobulinemic vasculitis.
  • It covers etiology, diagnostic methods, characteristic renal injuries, and current treatment strategies for HCV-related cryoglobulinemic vasculitis with kidney involvement.
  • Three clinical cases spanning decades demonstrate the long-term management and advancements in understanding this complex condition.

Impact:

  • Provides a comprehensive overview of cryoglobulinemia management.
  • Offers insights into the long-term outcomes of HCV-related cryoglobulinemic vasculitis.
  • Contributes to the understanding of renal complications and their treatment in vasculitis patients.

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