Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

9.1K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
9.1K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.7K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.7K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

4.0K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
4.0K
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

24.7K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
24.7K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.8K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.8K
Blood Flow01:29

Blood Flow

78.6K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
78.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD90 mediates gastric cancer immune evasion though regulating IGF2BP2 to stabilize the m6A-CD47/SIRPα axis.

Cancer cell international·2026
Same author

Associations of Family Physical Activity Support and 24-Hour Movement Behaviors with Physical Fitness in Preschool Children: A Focus on MVPA.

Healthcare (Basel, Switzerland)·2026
Same author

Guardians of immunity: the role of tumour-draining lymph node in cancer immunity.

Frontiers in cell and developmental biology·2026
Same author

Immortalized smooth muscle cells enhance in vitro vasculogenesis.

Research square·2026
Same author

Immortalized smooth muscle cells enhance in vitro vasculogenesis.

bioRxiv : the preprint server for biology·2026
Same author

A hybrid multiscale model for predicting CAR-T therapy outcomes in solid tumors.

Scientific reports·2026
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Related Experiment Video

Updated: Apr 5, 2026

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research
08:46

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research

Published on: March 22, 2024

1.8K

Mechanobiological oscillators control lymph flow.

Christian Kunert1, James W Baish2, Shan Liao3

  • 1Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; kuni@steele.mgh.harvard.edu.

Proceedings of the National Academy of Sciences of the United States of America
|August 19, 2015
PubMed
Summary
This summary is machine-generated.

Mathematical simulations reveal that two mechanobiological oscillators control lymphatic fluid transport. Calcium-mediated contractions and nitric oxide-induced relaxation create feedback loops, driving lymph flow and ensuring vessel function across varying pressures.

Keywords:
biological oscillatorcomputational modelcontrollymphaticmechanobiology

More Related Videos

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics
08:08

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics

Published on: December 8, 2011

14.2K
Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

7.2K

Related Experiment Videos

Last Updated: Apr 5, 2026

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research
08:46

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research

Published on: March 22, 2024

1.8K
Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics
08:08

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics

Published on: December 8, 2011

14.2K
Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

7.2K

Area of Science:

  • Mechanobiology
  • Systems Biology
  • Physiology

Background:

  • Cells sense and respond to physical forces, crucial for biological processes.
  • Collective cell organization can lead to emergent behaviors and tissue-level control.
  • Physical forces significantly influence complex collective behaviors in tissues.

Purpose of the Study:

  • To investigate the role of mechanobiology in lymphatic fluid transport.
  • To model the interplay of physical forces and cellular signaling in the lymphatic system.
  • To elucidate the mechanisms controlling lymphatic vessel oscillation and function.

Main Methods:

  • Utilized mathematical simulations to model lymphatic system dynamics.
  • Incorporated two complementary mechanobiological oscillators: Ca(2+)-mediated contraction and nitric oxide-induced relaxation.
  • Analyzed spatiotemporal dynamics of calcium and nitric oxide signaling.

Main Results:

  • Demonstrated that Ca(2+)-mediated contractions triggered by vessel stretch and nitric oxide-induced relaxation are sufficient for fluid transport control.
  • Predicted alternating spatiotemporal patterns of Ca(2+) and NO, forming feedback loops.
  • Showed that these mechanisms drive phasic contractions, regulate lymph flow, and are self-regulating and robust to pressure variations.

Conclusions:

  • The study provides an integrated framework for lymphatic function based on complementary mechanobiological oscillators.
  • This mechanism allows lymphatic vessels to adapt pumping activity to physiological demands.
  • Simulations accurately replicate experimental observations of pressure challenges and signaling pathway manipulations.