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Updated: Apr 5, 2026
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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
Published on: November 15, 2013
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1Klinik für Dermatologie, Venerologie und Allergologie, Allergie-Centrum-Charité, Charité-Universitätsmedizin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Deutschland. margitta.worm@charite.de.
Summary
Allergic contact eczema is common in children. Patch testing reveals nickel sulfate, fragrance mix I, and colophony as frequent sensitizers in children and adolescents, similar to adults.
Area of Science:
- Dermatology
- Allergology
- Epidemiology
Context:
- Allergic contact eczema is a prevalent condition in pediatric populations.
- Patch testing is a crucial diagnostic tool for identifying specific allergens.
- Previous research has established allergen prevalence in adults, but pediatric data requires further investigation.
Purpose:
- To analyze patch test data from a large cohort of children and adolescents.
- To determine the most common contact allergens in pediatric and adolescent populations.
- To compare sensitization patterns between pediatric, adolescent, and adult groups.
Summary:
- Analysis of 116,742 patch tests (2005-2014) including 925 children (0-12 years) and adolescents.
- Nickel sulfate, fragrance mix I, and colophony were the most frequent sensitizers in children, with prevalence rates of 8.5%, 5.5%, and 3.4% respectively.
- Adolescent sensitization patterns mirrored adult patterns, with notable exceptions in fragrance mix I sensitivity.
Impact:
- Findings highlight similarities in sensitization profiles between pediatric and adult populations.
- Identifies key allergens like nickel sulfate and fragrance mix I for targeted prevention strategies in younger demographics.
- Suggests a potential link between increased tattooing and sensitization to dyes like paraphenylenediamine in adolescents.
