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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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A multi-stimuli responsive, self-assembling, boronic acid dipeptide.

Brad H Jones1, Alina M Martinez, Jill S Wheeler

  • 1Electronic, Optical, and Nano Materials, Sandia National Laboratories, Albuquerque, NM 87185, USA. edspoer@sandia.gov.

Chemical Communications (Cambridge, England)
|August 20, 2015
PubMed
Summary
This summary is machine-generated.

Phenylalanine dipeptide modified with boronic acid self-assembles into hydrogels triggered by pH and ionic strength. Polyol binding to the boronic acid can reversibly control peptide assembly and disassembly.

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biomaterials Engineering

Background:

  • Peptide self-assembly is a key mechanism for developing advanced functional materials.
  • Boronic acid (BA) functionalization offers unique responsive properties to peptides.
  • Understanding stimuli-responsive hydrogelation is crucial for biomaterial applications.

Purpose of the Study:

  • To investigate the self-assembly behavior of phenylalanine dipeptide modified with boronic acid.
  • To explore the stimuli-responsive hydrogelation of this modified peptide.
  • To demonstrate the role of polyol binding in modulating peptide assembly.

Main Methods:

  • Synthesis of phenylalanine dipeptide with boronic acid functionality.
  • Characterization of self-assembly using techniques like microscopy and spectroscopy.
  • Induction of hydrogelation by manipulating pH and ionic strength.
  • Investigation of polyol interactions with the boronic acid moiety.

Main Results:

  • The modified dipeptide exhibits unique aqueous self-assembly behavior.
  • Hydrogelation is triggered by changes in pH and ionic strength, forming nanoribbon networks.
  • Polyol binding to the boronic acid functionality reversibly modulates the peptide between assembled and disassembled states.

Conclusions:

  • Phenylalanine dipeptide functionalized with boronic acid forms stimuli-responsive hydrogels.
  • pH and ionic strength are effective triggers for hydrogelation.
  • Polyol-peptide interactions provide a novel mechanism for controlling self-assembly in peptide-based materials.