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CXCL5 is associated with the increased risk of coronary artery disease

Xiao-Zeng Wang1, Li-Wen Liu, Xiao-Mo Du

  • 1aDepartment of Cardiology, Shengjing Hospital of China Medical University, Shenyang bDepartment of Cardiology, Cardiovascular Research Institute, the General Hospital of Shenyang, Military, Shenyang, Liaoning, China.

Coronary Artery Disease
|August 20, 2015
PubMed

Insights

Chemokine CXCL5 and its receptor CXCR2 are elevated in human atherosclerotic coronary arteries. A specific CXCL5 genetic variant may increase coronary artery disease (CAD) risk in Chinese Han individuals.

Area of Science:

  • Cardiovascular Research
  • Genetics
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) poses a significant global health burden.
  • The role of specific chemokines and their genetic variations in CAD pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the expression of CXCL5 and CXCR2 in human atherosclerotic coronary arteries.
  • To determine the association between a CXCL5 genetic variant and CAD susceptibility in a Chinese Han population.

Main Methods:

  • Immunohistochemistry and western blotting were used to detect CXCL5 and CXCR2 expression in coronary arteries.
  • Polymerase chain reaction (PCR)-direct sequencing analyzed the CXCL5 variant association with CAD.
  • Plasma CXCL5 levels were measured in a case-control study.

Main Results:

  • CXCL5 and CXCR2 expression were significantly higher in atherosclerotic plaques compared to normal arteries, increasing with lesion severity.
  • A functional nonsynonymous variant (-156 G/C) in the CXCL5 promoter was associated with CAD.
  • Plasma CXCL5 levels were elevated in CAD patients, particularly in those carrying the C allele of the -156 G/C variant.

Conclusions:

  • CXCL5 and CXCR2 are enriched in human atherosclerotic coronary arteries.
  • The CXCL5 promoter -156 G/C variant, specifically the C allele, may represent a genetic risk factor and an independent predictor for CAD.
  • CXCL5 shows potential as a molecular marker and therapeutic target for CAD.
Abstract

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