Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Redox Reactions01:24

Redox Reactions

59.4K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
59.4K
Redox Reactions01:27

Redox Reactions

1.4K
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
1.4K
Oxidation Numbers03:14

Oxidation Numbers

45.2K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
45.2K
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

4.2K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
4.2K
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

5.3K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
5.3K
Oxidation-Reduction Reactions03:11

Oxidation-Reduction Reactions

78.6K
Oxidation–Reduction Reactions
78.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GPR180 deficiency impairs mitochondrial function and insulin secretion in pancreatic β-cells.

Molecular metabolism·2026
Same author

Synergistic SGLT2 and GLP-1R targeting alleviates systemic inflammation-induced and M1 monocyte-driven endothelial dysfunction in coronary artery disease.

Cardiovascular diabetology·2026
Same author

Use of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors in Pulmonary Hypertension.

Circulation. Heart failure·2025
Same author

Role of adrenergic receptors and their blocking in cancer research.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Role of the sodium/calcium exchanger type 3 in cancer cells.

European journal of cell biology·2025
Same author

Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.

Nature cardiovascular research·2025

Related Experiment Video

Updated: Apr 5, 2026

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
07:33

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

16.1K

Calcium and ROS: A mutual interplay.

Agnes Görlach1, Katharina Bertram2, Sona Hudecova3

  • 1Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Redox Biology
|August 22, 2015
PubMed
Summary

Calcium and reactive oxygen species (ROS) are key signaling molecules in cells. Their interaction fine-tunes cellular processes, but dysfunction can lead to disease.

Keywords:
CalciumChannelsEndoplasmic reticulumMitochondriaNADPH oxidasesReactive oxygen species

More Related Videos

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

71.2K
Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.4K

Related Experiment Videos

Last Updated: Apr 5, 2026

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
07:33

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

16.1K
Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

71.2K
Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.4K

Area of Science:

  • Cellular Biology
  • Molecular Signaling

Background:

  • Calcium (Ca2+) acts as a crucial second messenger in intracellular and extracellular signaling pathways, regulating vital cellular functions.
  • Cellular processes are modulated by the calcium signaling network through buffers, pumps, and exchangers, ensuring function across a wide dynamic range.
  • Reactive oxygen species (ROS), once viewed as harmful byproducts, are now recognized as signaling molecules involved in growth and cell death.

Purpose of the Study:

  • To explore the intricate interplay between calcium and ROS signaling systems.
  • To understand the implications of this crosstalk in fine-tuning cellular signaling networks.
  • To investigate how dysregulation in either system can impact the other and contribute to disease pathogenesis.

Main Methods:

  • Review of existing literature on calcium signaling.
  • Analysis of studies investigating ROS generation and function.
  • Examination of research detailing the cross-talk between Ca2+ and ROS pathways.

Main Results:

  • Calcium and ROS signaling pathways exhibit a mutual interplay, crucial for precise regulation of cellular activities.
  • This interaction is vital for fine-tuning complex cellular signaling networks.
  • Dysfunction in either calcium or ROS signaling can adversely affect the other, potentially exacerbating cellular damage.

Conclusions:

  • The crosstalk between calcium and ROS signaling is fundamental for maintaining cellular homeostasis.
  • Disruptions in this signaling crosstalk are implicated in the pathogenesis of various disorders.
  • Further research into this interplay may reveal novel therapeutic targets for related diseases.