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Using the pathogen-host interactions database (PHI-base) to investigate plant pathogen genomes and genes implicated
Martin Urban1, Alistair G Irvine1, Alayne Cuzick1
1Department of Plant Biology and Crop Science, Rothamsted Research Harpenden, UK.
Frontiers in Plant Science
|August 25, 2015
Summary
Discovering new pathogen-host interactions is possible by combining mutant phenotype and genetic data. PHI-base is a curated database integrating this information for plant and animal pathogens.
Area of Science:
- Microbiology
- Genetics
- Bioinformatics
Background:
- Understanding pathogen-host interactions is crucial for controlling infectious diseases.
- Integrating diverse biological data types can reveal novel insights into these interactions.
Purpose of the Study:
- To present PHI-base, a manually curated database for pathogen-host interaction studies.
- To consolidate phenotype and genetic data for plant and animal pathogens.
Main Methods:
- Manual curation of peer-reviewed literature.
- Integration of mutant phenotype data with gene and protein information.
- Development of a multi-species database (PHI-base).
Main Results:
- PHI-base provides a centralized resource for pathogen-host interaction data.
- The database facilitates the study of mechanisms underlying pathogenicity.
- It supports research across various plant and animal pathogens.
Conclusions:
- PHI-base enables the discovery of novel pathogen-host interaction mechanisms.
- Data integration within PHI-base enhances biological research and disease control strategies.
Keywords:
comparative genomicsemerging diseasesgene regulatory networksgenetic recombinationhorizontal gene transferphytopathogensplant diseasesprotein interaction mappingMore Related Videos
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