Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

34.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.3K
Epigenetic Regulation01:37

Epigenetic Regulation

4.2K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.2K
Epigenetic Regulation01:46

Epigenetic Regulation

26.3K
26.3K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.9K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.9K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.3K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.3K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.9K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal separation increases anxiety-like phenotypes, fear responses, and alters <i>Bdnf</i> methylation in a predator odor exposure model of early life adversity.

Neurobiology of stress·2026
Same author

Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors.

Biological psychiatry global open science·2025
Same author

Gene Expression After Exercise Is Disrupted by Early-Life Stress.

Developmental psychobiology·2025
Same author

Developmental Changes in Locomotion and Sensorimotor Reflexes Following Spinal Cord Transection.

Developmental psychobiology·2024
Same author

Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex.

Neurotoxicology and teratology·2024
Same author

Epigenetic processes associated with neonatal spinal transection.

Developmental psychobiology·2024

Related Experiment Video

Updated: Apr 5, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

3.1K

Epigenetic mechanisms in learning and memory.

Jennifer Blaze1, Tania L Roth1

  • 1Department of Psychology, University of Delaware, Newark, DE, USA.

Wiley Interdisciplinary Reviews. Cognitive Science
|August 26, 2015
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms like DNA methylation and histone modifications are crucial for forming long-term memories. These processes also appear to enable the inheritance of acquired information across generations in rodents.

More Related Videos

Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

2.8K
Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

22.4K

Related Experiment Videos

Last Updated: Apr 5, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

3.1K
Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

2.8K
Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

22.4K

Area of Science:

  • Neurobiology
  • Cognitive Science
  • Epigenetics

Background:

  • Epigenetic mechanisms, including DNA methylation, histone modifications, and microRNA (miRNA) processing, are linked to activity-dependent gene expression.
  • These changes are essential for long-term memory formation and sustained behavioral changes.

Purpose of the Study:

  • To discuss the current understanding of epigenetic mechanisms in memory and behavior.
  • To explore two emerging viewpoints on the role of epigenetics in the central nervous system (CNS).

Main Methods:

  • Review of rodent studies investigating fear, recognition, spatial memories, and stress responses.
  • Analysis of research on epigenetic inheritance of acquired information in rodents.

Main Results:

  • Evidence suggests epigenetic mechanisms store information within the CNS, supporting memory formation.
  • Emerging research indicates epigenetics may facilitate the transmission of acquired traits across generations.

Conclusions:

  • Epigenetic mechanisms play a dual role in memory: information storage within the CNS and potential intergenerational inheritance.
  • Further research into these epigenetic pathways will enhance understanding of neurobiology and behavior across generations.