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Related Concept Videos

Somatic Spinal Reflexes01:22

Somatic Spinal Reflexes

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Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
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Related Experiment Video

Updated: Jun 9, 2025

Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat
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Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat

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Developmental Changes in Locomotion and Sensorimotor Reflexes Following Spinal Cord Transection.

Alleyna C Martes1, Aimee L Bozeman1, Julie Doell1

  • 1Department of Psychology, Idaho State University, Pocatello, Idaho, USA.

Developmental Psychobiology
|October 30, 2024
PubMed
Summary
This summary is machine-generated.

Spinal cord transection in neonatal rats reveals the lumbar spinal cord

Keywords:
behaviorneonatalopen fieldrecoverysensorimotorspinal cord injury

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Spinal cord injury (SCI) impacts sensorimotor function development.
  • The second postnatal week is critical for spinal sensorimotor development and recovery in rats.
  • Mechanisms of plasticity after neonatal SCI are not well understood.

Purpose of the Study:

  • To characterize developmental changes in weight-bearing locomotion and sensorimotor reflexes after SCI during the second postnatal week.
  • To establish a baseline for future research and potential interventions for neonatal SCI.

Main Methods:

  • Complete low-thoracic spinal cord transection (T8-T10) or sham surgery in rats on postnatal day 1.
  • Assessment of spontaneous locomotion, hindlimb weight bearing, and sensorimotor reflexes (surface righting, hindlimb placing, crossed-extensor reflex) on postnatal days 7, 14, and 21.

Main Results:

  • Spinal-transected and sham rats showed similar spontaneous locomotion, but differing hindlimb weight-bearing patterns over time.
  • Neonatal rats with SCI demonstrated preserved sensorimotor reflexes, indicating functional capacity of the isolated lumbar spinal cord.

Conclusions:

  • The neonatal lumbar spinal cord retains the ability to process sensory input and generate coordinated motor output post-transection.
  • Understanding these developmental trajectories is crucial for developing effective interventions to improve functional recovery after pediatric SCI.