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Amorphous solid dispersion technique for improved drug delivery: basics to clinical applications
Dinesh Kumar Mishra1, Vinod Dhote2, Arpit Bhargava3
1College of Pharmacy, IPS Academy, Indore, India. dineshdops@yahoo.com.
Drug Delivery and Translational Research
|August 27, 2015
Summary
Amorphous solid dispersions improve drug performance, especially for poorly water-soluble drugs. Key drug-polymer attributes are crucial for successful formulation development and clinical translation.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Solid dispersion techniques enhance drug performance in vivo.
- Amorphous drug-polymer solid dispersions are a key technology for poorly water-soluble drugs.
- Formulation success depends on drug-polymer stability, bioavailability, and manufacturability.
Purpose of the Study:
- To review the efficacy of amorphous solid dispersion in drug formulation.
- To highlight applications for poorly water-soluble compounds.
- To summarize parameters for solubility enhancement and clinical translation.
Main Methods:
- Literature review of amorphous solid dispersion techniques.
- Analysis of drug-polymer attributes influencing formulation performance.
- Summary of mechanisms for solubility enhancement.
Main Results:
- Amorphous solid dispersions significantly improve the performance of drug formulations.
- Physico-chemical stability, bioavailability, and manufacturability are critical factors.
- Key parameters for solubility enhancement and clinical efficacy are identified.
Conclusions:
- Amorphous solid dispersion is a vital technique for developing effective drug formulations.
- Understanding drug-polymer interactions is essential for successful translation to clinics.
- This review provides a comprehensive overview of the field for researchers and formulators.
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