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Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors
Published on: November 20, 2013
Selective detection of bacteria in urine with a long-range surface plasmon waveguide biosensor
Paul Béland1, Oleksiy Krupin2, Pierre Berini3
1Dept. of Biomedical Engineering, University of Ottawa, 161 Louis Pasteur, Ottawa, K1N 6N5, Canada.
Abstract:
Experimentation demonstrates long-range surface plasmon polariton waveguides as a useful biosensor to selectively detect gram negative or gram positive bacteria in human urine having a low concentration of constituents. The biosensor can detect bacteria at concentrations of 10(5) CFU/ml, the internationally recommended threshold for diagnostic of urinary tract infection. Using a negative control urine solution of bacterial concentration 1000☓ higher than the targeted bacteria, we obtain a ratio of 5.4 for the positive to negative signals.

