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Related Concept Videos

Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
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Surgical Menopause.

Maria Rodriguez1, Donna Shoupe2

  • 1Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 2622 South Tower, Los Angeles, CA 90048, USA.

Endocrinology and Metabolism Clinics of North America
|August 29, 2015
PubMed
Summary
This summary is machine-generated.

Women undergoing ovary removal before natural menopause experience more severe symptoms and increased health risks. Retaining ovaries offers survival benefits for those at low ovarian cancer risk, necessitating informed decision-making.

Keywords:
MenopauseOophorectomySurgical menopause

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Area of Science:

  • Reproductive Endocrinology
  • Gynecology
  • Oncology

Background:

  • Natural menopause involves common symptoms, but surgical menopause (oophorectomy) presents unique challenges.
  • Premenopausal oophorectomy, especially before age 45, leads to intensified and extended menopausal symptoms.
  • Ovary removal significantly elevates risks for mood disorders, cardiovascular disease, bone loss, sexual dysfunction, and cognitive decline.

Purpose of the Study:

  • To highlight the distinct health implications for women undergoing premenopausal oophorectomy.
  • To inform patients about the increased risks associated with ovary removal prior to natural menopause.
  • To emphasize the survival benefits of ovary retention in low-risk individuals.

Main Methods:

  • Comparative analysis of health outcomes in women with premenopausal oophorectomy versus the general population.
  • Review of literature on menopausal symptom severity and duration post-oophorectomy.
  • Assessment of risks for adverse mood, cardiovascular events, bone resorption, sexual dysfunction, and cognitive disorders.

Main Results:

  • Women with premenopausal oophorectomy report more severe and prolonged menopausal symptoms.
  • Increased incidence of adverse mood, heart disease, excessive bone resorption, sexual dysfunction, and cognitive disorders observed.
  • Ovary retention is associated with a survival benefit for women at low risk of ovarian malignancy.

Conclusions:

  • Premenopausal oophorectomy necessitates careful consideration due to amplified health risks and symptom burden.
  • Informed decision-making is crucial, weighing the risks of oophorectomy against the benefits of ovary retention.
  • Further research may explore targeted interventions to mitigate long-term adverse effects of surgical menopause.