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Syringe Injectable Electronics: Precise Targeted Delivery with Quantitative Input/Output Connectivity.

Guosong Hong1, Tian-Ming Fu1, Tao Zhou1

  • 1Department of Chemistry and Chemical Biology and ‡John A. Paulson School of Engineering and Applied Science, Harvard University , Cambridge, Massachusetts 02138, United States.

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Summary
This summary is machine-generated.

New syringe-injectable mesh electronics offer precise brain targeting and high connectivity for mapping and modulating neural activity. This technology enables minimally invasive, long-term brain monitoring and intervention.

Keywords:
Mesh electronicsconductive ink printingcontrolled injectiondense tissue/gelhigh yield input/output connectionstereotaxic surgeryultraflexible brain probe

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Syringe-injectable mesh electronics offer minimally invasive brain mapping and modulation.
  • Their ultraflexible, macroporous structure promotes neuron interaction but poses challenges for precise delivery and connectivity.

Purpose of the Study:

  • To develop a controlled injection method for precise, targeted delivery of mesh electronics.
  • To establish a reliable strategy for achieving high multichannel input/output (I/O) connectivity for these devices.

Main Methods:

  • Developed a controlled injection technique for precise (ca. 20 μm) delivery of mesh electronics while preserving structure.
  • Validated the injection method in hydrogels, ex vivo, and in vivo brain tissue using optical and microcomputed tomography.
  • Implemented an automated conductive ink printing method to connect mesh electronics to flexible flat cables for I/O connectivity.
  • Characterized printing parameters and noise performance, comparing to commercial bonding technologies.

Main Results:

  • Achieved targeted delivery of intact mesh electronics with high spatial precision.
  • Demonstrated up to 100% multichannel I/O connectivity using conductive ink printing.
  • Printing process yielded electrical performance comparable to commercial flip-chip bonding.
  • Validated the generality of the injection approach across different tissue types.

Conclusions:

  • Developed a controlled injection method for precise delivery of syringe-injectable mesh electronics.
  • Established a robust conductive ink printing strategy for high-connectivity interfaces.
  • These advancements facilitate in vivo applications of mesh electronics for long-term brain activity mapping and modulation.