Hypervalent Iodine(III) in Direct Oxidative Amination of Arenes with Heteroaromatic Amines
Srimanta Manna1,2, Polina O Serebrennikova1,3, Irina A Utepova3
1Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie , Otto-Hahn-Straße 11, 44227 Dortmund, Germany.
Abstract:
A novel, mild, and practical method of amination of simple nonfunctionalized arenes under metal free conditions has been developed. The approach allows coupling of electron-rich arenes with amino derivatives of electron-deficient heterocycles providing rapid access to scaffolds of bioactive compounds and is based on the application of the hypervalent iodine(III) reagent as an oxidant. Regioselective functionalization of C-H bonds of arenes by the formation of C-N bonds under organocatalytic conditions was demonstrated.
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