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Acitretin-induced spiny follicular hyperkeratosis
Mehmet Emin Yanik1, Gamze Erfan1, Hulya Albayrak1
1a Department of Dermatology and.
Cutaneous and Ocular Toxicology
|September 5, 2015
Summary
Spiny follicular hyperkeratosis (SFH) presents as flesh-colored spicules. This case study links SFH to acitretin use in a psoriasis patient, expanding known drug-induced causes.
Area of Science:
- Dermatology
- Dermatopathology
Background:
- Spiny follicular hyperkeratosis (SFH) is characterized by follicular hyperkeratotic spicules.
- SFH has been associated with various conditions, including adverse drug reactions.
- BRAF inhibitors and cyclosporine are previously implicated drugs.
Observation:
- A 51-year-old patient with psoriasis presented with spiny follicular hyperkeratosis.
- The patient was undergoing treatment with acitretin.
Findings:
- This case suggests a potential link between acitretin and the development of spiny follicular hyperkeratosis.
- Acitretin may be an additional drug to consider in the differential diagnosis of drug-induced SFH.
Implications:
- Expanding the understanding of drug-induced dermatoses.
- Informing clinical practice regarding potential side effects of acitretin.
- Highlighting the need for vigilance in identifying iatrogenic causes of follicular hyperkeratosis.
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