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Updated: Apr 4, 2026

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier
Published on: April 5, 2017
[Migration and pathogenicity of CD8 T cells in central nervous system diseases]
Guillaume Martin-Blondel1, Béatrice Pignolet2, Roland S Liblau3
1Département des maladies infectieuses et tropicales, hôpital universitaire de Toulouse, France - Inserm U1043, CNRS UMR 5282, centre de physiopathologie Toulouse-Purpan, hôpital Purpan, place du Docteur Baylac, 31024 Toulouse, France - Université Toulouse III, Toulouse, F-31000, France.
Abstract:
The implication of CD8 T cells in infectious and inflammatory diseases of the central nervous system has received increasing attention. CD8 T cells are crucial players of the adaptive immune system against neurotropic infections, but can also trigger tissue damage. Here we review the molecular mechanisms used by CD8 T cells to migrate into the central nervous system, and describe diseases that imply CD8 T cell-mediated pathogenicity. We also suggest therapeutic strategies targeting this population.
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