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Related Experiment Video

Updated: Apr 4, 2026

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

Interleukin-1β in intervertebral disk degeneration.

Wei Yang¹, Xiao-Hua Yu², Cheng Wang¹

¹Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|September 6, 2015

Summary

Interleukin-1 beta (IL-1β) drives intervertebral disc degeneration (IDD) by promoting inflammation and matrix breakdown. Inhibiting IL-1β may aid in extracellular matrix repair and disc regeneration for low back pain treatment.

Keywords:

Angiogenesis Apoptosis IDD IL-1 Inflammatory responses

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Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

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Published on: July 8, 2021

Area of Science:

Biomedical Science
Musculoskeletal Research
Inflammation Biology

Background:

Intervertebral disc degeneration (IDD) is a primary cause of low back pain and global musculoskeletal disability.
Interleukin-1 beta (IL-1β), a key inflammatory mediator, is highly expressed in degenerative disc tissues.
IL-1β contributes to pathological processes in IDD, including inflammation, matrix degradation, angiogenesis, and apoptosis.

Purpose of the Study:

To review the expression profiles, roles, and therapeutic potential of IL-1β in IDD.
To elucidate the signaling pathways of IL-1β in the context of intervertebral disc health.
To highlight the potential of IL-1β inhibition as a therapeutic strategy for degenerative disc disease.

Main Methods:

Literature review focusing on IL-1β signaling in IDD.
Analysis of studies detailing IL-1β expression in degenerative intervertebral disc (IVD) tissues and cells.
Synthesis of evidence on the pathological roles of IL-1β in IDD.

Main Results:

IL-1β is significantly upregulated in degenerative IVD and drives key pathological processes.
Inhibition of IL-1β has demonstrated potential in promoting extracellular matrix (ECM) repair.
Blocking IL-1β activity may offer protective effects against further disc degeneration and aid regeneration.

Conclusions:

IL-1β plays a critical role in the pathogenesis of IDD.
Targeting IL-1β presents a promising therapeutic avenue for managing degenerative disc disease.
Further research into IL-1β-based interventions could lead to novel treatments for low back pain.