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Related Concept Videos

Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Oral Drug Delivery Systems: Continuous-Release Systems01:26

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Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Application of monodirectional Janus patch to oromucosal delivery system.

Jae Bem You1, Ah Young Choi2, Jieung Baek1

  • 1Department of Chemical and Biomolecular Engineering and Graphene Research Center (GRC), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.

Advanced Healthcare Materials
|September 9, 2015
PubMed
Summary

Researchers developed a Janus drug delivery patch for controlled transmucosal administration. This innovative patch prevents unwanted drug release in mucous environments, enhancing drug permeation through skin and mucosal tissues.

Keywords:
Janus patchdrug deliveryinitiated chemical vapor deposition (iCVD)monodirectionaloromucosa

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Transmucosal drug delivery offers advantages over oral administration, including precise dose control and bypassing first-pass metabolism.
  • A key challenge is managing drug dissolution and diffusion in mucosal environments, which can lead to uncontrolled release.
  • Developing directional drug delivery systems is crucial for efficient and targeted transmucosal therapies.

Purpose of the Study:

  • To design and fabricate a Janus drug delivery patch with monodirectional diffusion properties.
  • To overcome the issue of unwanted drug release caused by body fluids in mucosal environments.
  • To evaluate the efficacy of the Janus patch for enhanced transmucosal drug delivery.

Main Methods:

  • Fabrication of a Janus substrate by coating polyester fabric with a hydrophobic polymer using initiated chemical vapor deposition.
  • Selective rendering of hydrophilicity on one surface via base-catalyzed hydrolysis.
  • Loading resveratrol into a hydrogel and coating it onto the hydrophilic surface of the Janus substrate.
  • In vitro and ex vivo evaluation of fluid penetration blocking and drug permeation through hairless mouse skin and reconstructed human mucosae.

Main Results:

  • The fabricated Janus patch demonstrated efficient blocking of fluid penetration in a mucous environment.
  • Transmucosal delivery of resveratrol using the Janus patch showed significantly higher permeation flux compared to a bare control patch.
  • The patch effectively facilitated unidirectional drug diffusion, confirming its monodirectional property.

Conclusions:

  • The developed Janus drug delivery patch provides an effective solution for controlled transmucosal drug delivery.
  • This technology can prevent premature drug dissolution and unwanted release in mucosal environments.
  • The Janus patch holds potential as a versatile tool for enhancing the delivery of various drugs via mucosal routes.