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Diffusion-weighted magnetic resonance imaging in patients with prostate cancer treated with radiotherapy
Giancarlo Iannelli1, Rocchina Caivano1, Luciana Rago1
1Radiology Department, IRCCS-CROB, Rionero in Vulture (Potenza) - Italy.
Aims:
To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT).
Methods:
A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma, underwent MRI examination before and after local RT for the assessment of response to treatment. Apparent diffusion coefficient (ADC) values were calculated and compared.
Results:
Before RT, DWI shows pathologic restriction of signal, while after RT pathologic restriction of signal was reduced or disappeared. The ADC values were significantly increased after therapy (p<0.05).
Conclusions:
The use of DWI with ADC measurements may be an imaging biomarker in the assessment of prostate cancer.
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