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CD5 as a Target for Immune-Based Therapies.

Marta Consuegra-Fernández¹, Fernando Aranda¹, Inês Simões¹

¹Group of Immune Receptors of the Innate and Adaptive System, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Critical Reviews in Immunology

|September 10, 2015

Summary

CD5, a T-lymphocyte surface receptor, regulates immune responses and is found on regulatory T and B cells. Its role in modulating immune signals makes CD5 a potential target for immunotherapies in autoimmune diseases, cancer, and infections.

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Area of Science:

Immunology
Cell Biology
Molecular Medicine

Background:

CD5 is an early-identified surface receptor on T lymphocytes.
CD5 is highly expressed on regulatory T cells and a subset of regulatory B cells.
CD5 associates with T-cell receptor (TCR) and B-cell receptor (BCR) complexes.

Purpose of the Study:

To review the function of CD5 in immune response regulation.
To explore CD5's involvement in health and disease.
To assess CD5 as a therapeutic target for various conditions.

Main Methods:

Literature review of existing data on CD5 function.
Analysis of CD5's role in immune signal modulation.
Examination of CD5's association with antigen receptors and pathogen patterns.

Main Results:

CD5 negatively modulates TCR- and BCR-mediated signaling.
CD5 binds pathogen-associated molecular patterns.
CD5's expression on regulatory immune cells highlights its regulatory role.

Conclusions:

CD5's multifaceted functions position it as a key regulator of immune responses.
Targeting CD5 offers potential for novel immunotherapies.
Further research is needed to overcome challenges in developing CD5-based therapeutics for autoimmune diseases, cancer, and infections.