Related Experiment Video
Updated: Apr 4, 2026
11:23
An Open-Source Normothermic Perfusion System Designed for Research Scientists
Published on: July 18, 2025
1.4K
Versatile minimized system--a step towards safe perfusion
Y M Ganushchak1, E P J Körver2, Y Yamamoto3
1Department of Cardiothoracic Surgery, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands y.ganushchak@mumc.nl.
Perfusion
|September 11, 2015
Summary
Minimizing cardiopulmonary bypass (CPB) circuits offers benefits but has drawbacks. A new versatile minimized system (VMS) provides the advantages of minimized CPB while retaining the safety and adaptability of conventional systems.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Perfusion Technology
Background:
- Minimized cardiopulmonary bypass (CPB) systems reduce inflammatory responses and transfusion needs.
- However, minimized CPB systems present challenges including pressure fluctuations, gaseous microemboli risk, and limited adaptability for complications.
Purpose of the Study:
- To develop a versatile minimized system (VMS) that combines the benefits of minimized CPB with the safety and flexibility of conventional systems.
- To address the limitations of existing minimized CPB circuits.
Main Methods:
- Development of a VMS with a 600 ml priming volume.
- Incorporation of a compliance chamber in the venous line to manage pressure fluctuations and act as a bubble trap.
- Integration of a parallel, switchable open venous reservoir for cardiotomy suction and easy conversion to an open system.
Main Results:
- The VMS effectively decreases pressure fluctuations and mitigates risks associated with kinetic-assisted drainage.
- The system allows for cardiotomy suction and can be readily converted to an open system for managing complications.
- The VMS maintains the advantages of minimized circuits while offering enhanced safety and versatility.
Conclusions:
- The developed versatile minimized system (VMS) successfully integrates the advantages of minimized CPB with the adaptability of conventional systems.
- This innovative VMS enhances patient safety and perfusionist response capabilities during complex cardiac surgeries.
