[Changes in the clinical picture of chorea minor]

The paper dealt with the change in clinical picture of chorea minor. It used to be a very frequent disease but now it is all the rarer appearance and it always occurs as a complication of rheumatic disease. Except for its rarer frequency, once it has occurred it is more often complicated by cardiac incidents, the course of disease is longer and more resistant to therapy and is accompanied by psychic changes without frequent relapses observed in its previous appearances. Contemporary immunologic knowledge of this field has detected the complex neuroimmunologic changes taking place in CNS. According to the authors' opinion, modification of the clinical picture is the sequel of the broad application of antibiotics in general but the prevalence of chorea in girls keeps remaining unclear. However, there is no specific attritude toward neuroimmunologic mechanism so far, because previous knowledge of this problem is lacking.