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Surface-Induced Polymorphism as a Tool for Enhanced Dissolution: The Example of Phenytoin

Daniela Reischl1, Christian Röthel2, Paul Christian2

  • 1Institute for Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens University of Graz , Universitätsplatz 1, 8010 Graz, Austria.

Crystal Growth & Design
|September 15, 2015
PubMed
Summary

A new surface-induced polymorph (SIP) of phenytoin was created in thin films. This novel phenytoin form shows improved dissolution performance, offering a promising approach for enhancing drug bioavailability.

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