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Related Experiment Videos

Interhemispheric connections differ between symmetrical and asymmetrical brain regions.

G D Rosen1, G F Sherman, A M Galaburda

  • 1Dyslexia Research Laboratory, Beth Israel Hospital, Boston, MA 02215.

Neuroscience
|January 1, 1989
PubMed
Summary

Brain region asymmetry in Wistar rats correlates with reduced axonal connections. Larger, symmetrical brain regions showed decreased axonal termination, suggesting developmental mechanisms influence cerebral cortex structure.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Comparative Neuroanatomy

Background:

  • Corpus callosum connects brain hemispheres, crucial for interhemispheric communication.
  • Brain asymmetry is observed in various species, with potential functional implications.
  • Callosal connectivity development is complex and influenced by various factors.

Purpose of the Study:

  • To investigate the relationship between volumetric asymmetry in the neocortical region SM-I and callosal axonal degeneration in adult male Wistar rats.
  • To explore how brain asymmetry affects the density and distribution of axonal terminations.
  • To postulate mechanisms for the development of architectonic asymmetry in the cerebral cortex.

Main Methods:

  • Coronal brain sections from adult male Wistar rats that underwent corpus-callosectomy.

Related Experiment Videos

  • Staining with Cresyl Violet for Nissl substance and Fink-Heimer method for axonal degeneration.
  • Volumetric measurements of neocortical region SM-I asymmetry and computation of terminal degeneration percentage.

    • Main Results:

    • A negative correlation was found between the asymmetry coefficient and total architectonic volume.
    • Increased volumetric asymmetry was associated with a decreased percentage of axonal termination.
    • The decrease in axonal termination was partly due to fewer patches of callosal axonal termination.

    Conclusions:

    • Symmetrical brain regions are larger than the average of corresponding regions in asymmetrical brains.
    • Increased brain asymmetry is linked to reduced callosal connectivity, particularly in the number of termination patches.
    • Developmental mechanisms influencing callosal connectivity may play a role in the emergence of cerebral cortex architectonic asymmetry.