SYNTHESIS AND APPLICATIONS OF Fe3O4/SiO2 CORE-SHELL MATERIALS

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• Core-shell nanoparticles, specifically magnetite/silica, integrate magnetic and fluorescent properties.
• These multifunctional nanoparticles are synthesized using methods like Stöber and microemulsion.
• Functionalization with aminosilanes enhances their utility for biological and environmental applications.

Purpose of the Study:

• To review advances in magnetite/silica core-shell nanoparticles.
• To highlight their applications in medicine and environmental protection.
• To summarize synthesis and functionalization methods.

Main Methods:

• Synthesis of silica-coated magnetite nanoparticles via Stöber and microemulsion methods.
• Functionalization of silica shell with aminosilanes for specific binding.
• In vitro testing on human cancerous cell lines (A549, breast, cervical, THP-1).

Main Results:

• Nanoparticles demonstrate efficacy in stem cell labeling, drug delivery, and hyperthermia.
• Functionalized nanoparticles are effective for immobilizing biological entities and adsorbing heavy metals.
• Core-shell nanoparticles with cytostatics show potential for cancer therapy by inhibiting proliferation and inducing apoptosis.

Conclusions:

• Magnetite/silica core-shell nanoparticles are versatile platforms for diverse biomedical and environmental applications.
• Their dual functionality enables targeted drug delivery, cancer therapy, and environmental remediation.
• Continued research promises further advancements in their therapeutic and environmental impact.