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Published on: March 29, 2017
Catecholamines and acetylcholine are key regulators of the interaction between microbes and the immune system
Leon Islas Weinstein1, Alberto Revuelta1, Rogelio Hernandez Pando1
1Department of Pathology, Experimental Pathology Section, The Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico.
Abstract:
Recent studies suggest that catecholamines (CAs) and acetylcholine (ACh) play essential roles in the crosstalk between microbes and the immune system. Host cholinergic afferent fibers sense pathogen-associated molecular patterns and trigger efferent cholinergic and catecholaminergic pathways that alter immune cell proliferation, differentiation, and cytokine production. On the other hand, microbes have the ability to produce and degrade ACh and also regulate autogenous functions in response to CAs. Understanding the role played by these neurotransmitters in host-microbe interactions may provide valuable information for the development of novel therapies.
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