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Related Experiment Video

Updated: Apr 3, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

38.1K

Noninvasive prenatal diagnosis.

Wei-Lun Cheng1, Ching-Hua Hsiao2, Hua-Wei Tseng1

  • 1Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

Taiwanese Journal of Obstetrics & Gynecology
|September 19, 2015
PubMed
Summary

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Noninvasive prenatal diagnosis aims to isolate rare fetal cells from maternal blood. Microfluidic systems offer an efficient, cost-effective solution for this crucial advancement in prenatal testing.

Area of Science:

  • Biomedical Engineering
  • Genetics
  • Obstetrics

Background:

  • Prenatal diagnosis is vital for fetal health assessment and treatment planning.
  • Invasive methods like amniocentesis carry risks.
  • Noninvasive prenatal diagnosis (NIPD) is a critical goal to ensure fetal safety.

Purpose of the Study:

  • To highlight the importance of efficient fetal cell separation for NIPD.
  • To introduce microfluidic systems as a key technology for isolating rare fetal cells.
  • To discuss the potential of microfluidics in advancing NIPD.

Main Methods:

  • Review of microfluidic systems for cell separation.
  • Focus on applications in isolating rare cells from biological samples.
  • Discussion of automation and high-throughput capabilities.
Keywords:
microfluidic systemnoninvasive prenatal diagnosisprenatal examination

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Main Results:

  • Microfluidic systems demonstrate efficiency in analyzing small sample volumes.
  • These systems offer advantages like low cost and design flexibility.
  • Microfluidic disks enable automated, high-throughput rare cell selection.

Conclusions:

  • Microfluidic technology is a promising solution for fetal cell separation in NIPD.
  • The development of microfluidic applications for NIPD holds significant potential.
  • Further advancements in microfluidics will enhance NIPD accessibility and effectiveness.