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Updated: Apr 3, 2026

Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
Published on: September 15, 2011
Epileptogenesis
Asla Pitkänen1, Katarzyna Lukasiuk2, F Edward Dudek3
1Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland Department of Neurology, Kuopio University Hospital, FI-70211 Kuopio, Finland.
Abstract:
Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. However, thanks to active research, a large number of animal models have become available for search of molecular mechanisms of epileptogenesis. The first glimpses of treatment targets and biomarkers that could be developed to become useful in clinic are in sight. However, the heterogeneity of the epilepsy condition, and the dynamics of molecular changes over the course of epileptogenesis remain as challenges to overcome.
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