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Updated: Apr 3, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Genetically engineered mouse models for studying inflammatory bowel disease.

Atsushi Mizoguchi¹, Takahito Takeuchi¹, Hidetomo Himuro¹

¹Department of Immunology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

The Journal of Pathology

|September 22, 2015

Summary

This summary is machine-generated.

Genetically engineered mouse models are crucial for understanding inflammatory bowel disease (IBD) mechanisms and developing new therapies. Over 74 strains have been developed, aiding research into IBD susceptibility genes and treatments.

Keywords:

ER stress IBD susceptibility gene epithelial barrier immunoregulation knockout mice mouse models

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Area of Science:

Gastroenterology
Immunology
Genetics

Background:

Inflammatory bowel disease (IBD) is a chronic intestinal condition with complex genetic, immune, and environmental underpinnings.
Mouse models are indispensable tools for dissecting IBD pathogenesis and evaluating therapeutic interventions.

Purpose of the Study:

To review the landscape of genetically engineered mouse models used in IBD research.
To highlight the contributions of these models to understanding IBD mechanisms and gene functions.

Main Methods:

Compilation and description of over 74 genetically engineered mouse strains that spontaneously develop intestinal inflammation.
Analysis of how these models incorporate human IBD susceptibility genes.
Inclusion of advanced techniques like cell-specific and inducible knockout systems.

Main Results:

Mouse models have significantly advanced the understanding of IBD.
Approximately 20 models carry known human IBD susceptibility genes.
Advanced genetic tools enhance the discovery of novel therapeutic rationales.

Conclusions:

Genetically engineered mouse models are vital for IBD research, offering insights into disease mechanisms.
These models facilitate the identification and validation of therapeutic targets for IBD.
Continued development and application of sophisticated mouse models will drive future IBD treatment strategies.