[Does the serum AMH assay allow predicting reliably female fertility?]

Area of Science:

• Reproductive Endocrinology
• Gynecology

Background:

• Anti-Müllerian hormone (AMH) is produced by granulosa cells in growing ovarian follicles.
• AMH measurement correlates strongly with antral follicle count, serving as a key indicator of ovarian reserve.
• AMH levels exhibit high reproducibility with minimal variation across menstrual cycles.

Purpose of the Study:

• To evaluate the utility of AMH as a marker in female reproductive health.
• To assess the role of AMH in predicting fertility and managing infertility conditions.
• To determine the application of AMH in assisted reproductive technology and oncology patient care.

Main Methods:

• Measurement of serum AMH levels.
• Correlation analysis with antral follicle count.
• Clinical application in various gynecological and fertility contexts.

Main Results:

• AMH is a reliable quantitative marker of ovarian reserve but does not assess oocyte quality.
• AMH is valuable in specific conditions like premature ovarian failure and polycystic ovary syndrome.
• AMH is crucial in assisted reproductive technology for treatment selection and stimulation protocols.
• AMH is informative for monitoring cancer patients undergoing ovariotoxic treatments.

Conclusions:

• AMH is indispensable in the management and treatment of female infertility.
• While not a direct pregnancy predictor, AMH provides critical insights into reproductive potential.
• AMH plays a vital role in personalized fertility care and patient monitoring.