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Published on: August 21, 2018
Synthesis and base pairing studies of geranylated 2-thiothymidine, a natural variant of thymidine
Rui Wang1, Srivathsan V Ranganathan2, Maria Basanta-Sanchez2
1Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA. jsheng@albany.edu and The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave. Albany, NY 12222, USA.
Abstract:
The synthesis and base pairing of DNA duplexes containing the geranylated 2-thiothymidine have been investigated. This naturally existing hydrophobic modification could grant better base pairing stability to the T-G pair over normal T-A and other mismatched pairs in the duplex context. This study provides a potential explanation for the different codon recognition preferences of the geranylated tRNAs.
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