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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Contrast-associated Acute Kidney Injury
Steven D Weisbord1, Paul M Palevsky2
1Renal Section, VA Pittsburgh Healthcare System, Room 7E120 (111F-U), University Drive, Pittsburgh, PA 15240, USA; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, A919 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
Critical Care Clinics
|September 28, 2015
Summary
Contrast-associated acute kidney injury (CAAKI) is a common complication. Key risk factors include kidney disease, diabetes, and dehydration, leading to adverse outcomes.
Area of Science:
- Nephrology
- Cardiology
- Radiology
Background:
- Contrast-associated acute kidney injury (CAAKI) is a frequent iatrogenic complication.
- Identifying and mitigating CAAKI risk factors is crucial for patient outcomes.
Purpose of the Study:
- To review the primary risk factors for CAAKI.
- To discuss the adverse outcomes associated with CAAKI.
- To provide guidance on managing patients with risk factors undergoing procedures.
Main Methods:
- Literature review and synthesis of existing data on CAAKI.
- Analysis of risk factors including renal impairment, diabetes, and volume status.
- Examination of short-term and long-term consequences of CAAKI.
Main Results:
- Underlying renal impairment, diabetes with kidney disease, and intravascular volume depletion are principal CAAKI risk factors.
- CAAKI is linked to adverse outcomes, including mortality and accelerated chronic kidney disease progression.
- Causality of these associations requires further investigation.
Conclusions:
- Patients with chronic kidney disease and other CAAKI risk factors presenting with acute coronary syndrome require indicated angiographic procedures.
- Careful patient selection and risk factor management are essential.
- Further research is needed to confirm causal links between CAAKI and long-term outcomes.
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