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Updated: Apr 3, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Contrast-associated Acute Kidney Injury
Steven D Weisbord1, Paul M Palevsky2
1Renal Section, VA Pittsburgh Healthcare System, Room 7E120 (111F-U), University Drive, Pittsburgh, PA 15240, USA; Renal-Electrolyte Division, University of Pittsburgh School of Medicine, A919 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
Abstract:
Contrast-associated acute kidney injury (CAAKI) is a common iatrogenic condition. The principal risk factors for CAAKI are underlying renal impairment; diabetes in the setting of kidney disease; and intravascular volume depletion, effective or absolute. CAAKI is associated with serious adverse short-term and long-term outcomes, including mortality and more rapidly progressive chronic kidney disease, although the causal nature of these associations remains unproved. Patients with chronic kidney disease and other risk factors for CAAKI who present with acute coronary syndrome should undergo indicated angiographic procedures.
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