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Related Concept Videos

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Related Experiment Video

Updated: Apr 2, 2026

Clinical Imaging of Microwave Mammography
05:28

Clinical Imaging of Microwave Mammography

Published on: November 14, 2025

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ESTIMATES OF BREAST CANCER GROWTH RATE FROM MAMMOGRAMS AND ITS RELATION TO TUMOUR CHARACTERISTICS.

D Förnvik1, K Lång2, I Andersson2

  • 1Medical Radiation Physics, Translational Medicine, Lund University, Malmö, Sweden Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden daniel.fornvik@med.lu.se.

Radiation Protection Dosimetry
|September 28, 2015
PubMed
Summary
This summary is machine-generated.

The tumor volume-doubling time in invasive breast cancers varies significantly by grade. Faster growth rates in Grade III tumors suggest this mammography metric offers valuable prognostic insights for patient care.

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Accurate assessment of breast cancer growth dynamics is crucial for effective treatment planning.
  • Serial mammography allows for non-invasive estimation of tumor volume changes over time.

Purpose of the Study:

  • To investigate the tumor volume-doubling time (TVDT) in invasive breast cancers using serial mammography.
  • To correlate TVDT with histopathological findings and patient characteristics.
  • To evaluate the prognostic significance of TVDT in clinical decision-making.

Main Methods:

  • Analysis of 31 invasive breast cancer cases with at least two serial mammograms.
  • Calculation of average tumor volume-doubling time for all subtypes.
  • Statistical analysis including multiple linear regression to identify associations with histopathological factors.

Main Results:

  • The average TVDT across all invasive breast cancer subtypes was 282 days.
  • Grade III breast cancers exhibited a significantly shorter TVDT (105 days) compared to Grade I (296 days) and Grade II (353 days) tumors (p = 0.002).
  • TVDT was positively associated with patient age, histological grade, and progesterone receptor expression, and inversely associated with lymph node involvement, human epidermal growth factor receptor 2, and Ki-67 expression (p < 0.001).

Conclusions:

  • Tumor volume-doubling time derived from serial mammography provides valuable prognostic information.
  • This imaging-based metric can aid in clinical decision-making for invasive breast cancer management.